Choosing between QuickBooks Online and Desktop depends on your business needs. QuickBooks Online offers cloud-based access, real-time collaboration, and automatic updates—perfect for remote teams and growing businesses. It includes mobile access, third-party app integrations, and flexible subscription plans. QuickBooks Desktop, on the other hand, is ideal for businesses needing advanced features like industry-specific reporting and job costing, with one-time payment options available. While Online suits service-based businesses and startups, Desktop is better for product-based companies with complex accounting needs. Understanding the differences helps ensure you choose the version that aligns with your workflow and budget.